SUICIDAL IDEATION IN DEPRESSED PATIENTS AND THERAPEUTIC ROLE OF VORTIOXETINE: SECONDARY ANALYSIS OF A LARGE PROSPECTIVE STUDY

  • Prof Nasim Chaudhry Pakistan Institute of Living and Learning
  • Tayyeba Kiran Pakistan Institute of Living and Learning
  • Ameer B Khoso Pakistan Institute of Living and Learning
  • Zaib un Nisa Pakistan Institute of Living and Learning
  • Prof Ghullam Rasool Balochistan Institute of Psychiatry and Behavioral Sciences
  • Prof Imtiaz Dogar Faisalabad Medical University
  • Dr. Khalid Mahmood
  • Syed Usman Hamdani
  • Dr. Ali Bux Rajper
  • Prof Fareed Minhas
  • Prof Imran B Chaudhry Ziauddin University Hospital

Abstract

OBJECTIVES

To explore the association of different variables with suicidal ideation and the role of vortioxetine in managing suicidal ideation in depressed patients in Pakistan.

STUDY DESIGN

This is a secondary analysis of a large, multi-centre, non-interventional, prospective longitudinal study with patients who were prescribed Vortioxetine.

PLACE AND DURATION OF THE STUDY

The main study was conducted in 16 psychiatry outpatient clinics in 8 cities across Pakistan.

SUBJECTS AND METHODS

A total of 498 depressed patients aged 18- 65 years participated in the study. Suicidal ideation was measured using item # 9 of the Patient Health Questionnaire (PHQ-9). Participants were assessed at baseline, 1 week, 1-month and 3-month after treatment initiation.

RESULTS:

There was statistically significant reduction in reporting of suicidal ideation from 80% at baseline to 13% at outcome assessment. There was significant positive correlation between suicidal ideation and cognitive dysfunction on Perceived Deficits Questionnaire (PDQ) and suicidal ideation and depression scores on PHQ-9. There was a statistically significant difference between those who reported suicidal ideation and those who did not report suicidal ideation on the CGI-severity scale both at baseline and at 3-month outcome assessment.

CONCLUSION

Suicidal ideation is common in depressed patients and this study demonstrated that suicidal ideation was reduced significantly with Vortioxetine treatment.

KEY WORDS

Suicidal ideations, Vortioxetine, Depression.

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Author Biographies

Prof Nasim Chaudhry, Pakistan Institute of Living and Learning

CEO-Pakistan Institute of Living and Learning 

Tayyeba Kiran, Pakistan Institute of Living and Learning

Assistant Director- Pakistan Institute of Living and Learning 

Ameer B Khoso, Pakistan Institute of Living and Learning

Assistant Director-Pakistan Institute of Living and Learning 

Zaib un Nisa, Pakistan Institute of Living and Learning

Research Associate-Pakistan Institute of Living and Learning

Prof Imran B Chaudhry, Ziauddin University Hospital

Professor and Chairman, Department of Psychiatry, Ziauddin University Hospital

Published
2021-09-30
How to Cite
1.
Chaudhry N, Kiran T, Ameer B Khoso, Zaib un Nisa, Rasool G, Dogar I, Mahmood K, Hamdani SU, Rajper AB, Minhas FA, Imran B Chaudhry. SUICIDAL IDEATION IN DEPRESSED PATIENTS AND THERAPEUTIC ROLE OF VORTIOXETINE: SECONDARY ANALYSIS OF A LARGE PROSPECTIVE STUDY. J Pak Psychiatr Soc [Internet]. 2021Sep.30 [cited 2024Dec.22];18(03):15-1. Available from: https://jpps.pk/index.php/journal/article/view/118

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