PREVIDA- IMPACT OF VORTIOXETINE ON MAJOR DEPRESSIVE DISORDER AND PERCEIVED COGNITIVE DYSFUNCTION- A MULTICENTER STUDY
Abstract
Exploring Cognitive Dysfunction and Treatment Efficacy of Vortioxetine in Major Depressive Disorder: Previda in Pakistan
Objective:
To investigate the prevalence of cognitive Dysfunction in major depressive disorder (MDD) and evaluate the efficacy of vortioxetine in treating both depressive symptoms and cognitive dysfunction.
Design:
Prospective, Cross-sectional and multicentered
Place & Duration of Study:
The study was conducted in 16 Psychiatric outpatients Departments in Pakistan, for a period of 12 weeks.
Patients & Methods:
A total of 498 participants with diagnosis of major depression disorder were included in the study. The severity of depression and cognitive dysfunction were measured. The Psychiatrists prescribed vortioxetine to participants after assessments by Clinical Global Impression-Severity scale (CGI-S), the Patient Health Questionnaire-9 (PHQ-9).and Perceived Deficits Questionnaire (PDQ). The variables were again assessed after treatment initiation at 1 week (+/– 3 days), 1 month ( +/– 7 days) and 3 months(+/– 14 days).
Results
Upon completion of a 12 week treatment regimen involving vortioxetine subjects with MDD showced notable improvements in mean PHQ 9 and PDQ scores. This signifies vortioxetines efficiency in alleviating depressive symptoms alongside cognitive deficits within individuals diagnosed with MDD. There was positive correlation noted between PHQ 9 and PDQ scores, demonstrating a close association linking depressive symptoms to cognitive dysfunction.
Conclusions
The study findings shows the effectiveness of vortioxetine in addressing cognitive deficits in patients diagnosed with MDD while also improving depressive symptoms. These results highlight the potential of vortioxetine as a valuable treatment alternative for individuals facing cognitive impairment alongside their MDD diagnosis. Further research is necessary to verify these results and consider their applicability to diverse populations.
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