ASSOCIATION OF LIPID PROFILE WITH DEPRESSIVE FEATURES IN YOUNG HYPERTENSIVES

  • Ravi Gupta Department of Psychiatry, SMS Medical College, JLN Marg, Jaipur, India.
  • Ram Kumar Solanki Department of Psychiatry, SMS Medical College, JLN Marg, Jaipur, India.
  • Vaibhav Dubey Department of Psychiatry, SMS Medical College, JLN Marg, Jaipur, India.
  • Purav Kumar Midha Department of Psychiatry, SMS Medical College, JLN Marg, Jaipur, India.
  • Vijay Pathak Department of Cardiology, SMS Medical College, JLN Marg, Jaipur, India.

Abstract

Objectives: To find out

(a) the correlation of various components of serum lipids with depression score; (b) whether severity of depression differ between the people with normal serum lipids & dyslipidemia;and (c) whether the lipid components differ between depressed and non-depressed people.
Design: Cross Sectional Cohort study.
Place and duration of the study: This study was conducted at Sawai Man Singh Medical College and
Hospital, Jaipur, India from January 2001 to June 2002.
Subjects and Methods: 100 young primary hypertensive subjects were included in this study. Their fasting blood lipid profile was ascertained and their depressive feelings were rated with the help of HAM-D.
Results: In this study, total lipids, high density lipoprotein, low density lipoprotein, very low density lipoproteins and triglycerides were positively correlated with the HAM D score. Depressed subjects (HAMD>17) had higher levels of total lipids (P=0.002), HDL (P=0.04), VLDL (P=0.02) and TG (P=0.001). Similarly subjects with higher cholesterol levels (P=0.05), normal HDL (P=0.003), normal LDL (P<0.001); higher VLDL (P=0.002) and higher TGs (P<0.001) had higher scores on HAM-D.
Conclusions: This study suggests that low HDL, high LDL protects from the depression. On the other hand, high cholesterol, VLDL and TG increase the risk of depression.

Key words: Hypertension, Young, Lipid profile, Depressive features.

Downloads

Download data is not yet available.

References

Rabe-Jablonska J, Poprawska I. Levels of serum total cholesterol and LDL-cholesterol in patients with major

depression in acute period and remission. Med Sci Monit 2000;6:539-47.

Nakao M, Yano E. Relationship between major depression and high serum cholesterol in Japanese men. Tohoku J Exp Med 2004:204: 273-87.

Kilkens TO, Honig A, Maes M. Fatty acid profile and affective dysregulation in irritable bowel syndrome. Lipids 2004;39:425-31.

Petrlova B, Rosolova H, Hess Z, Podlipny J, Simon J. Depressive disorders and the metabolic syndrome of insulin resistance. Semin Vasc Med 2004;4:161-5.

Ergun UG, Uguz S, Bozdemir N, Güzel R, Burgut R, Saatçi E, Akpinar E. The relationship between cholesterol levels and depression in the elderly. Int J Geriatr Psychiatry 2004;19:291-6.

Deisenhammer EA, Kramer-Reinstadler K, Liensberger D, Kemmler G, Hinterhuber H, Fleischhacker WW. No

evidence for an association between serum cholesterol and the course of depression and suicidality. Psychiatry

Res 2004;121:253-61.

Huang TL, Chen JF. Lipid and lipoprotein levels in depressive disorders with melancholic feature or atypical feature and dysthymia. Psychiatry Clin Neurosci2004;58:295-9.

Lalovic A, Merkens L, Russell L, Arsenault-Lapierre G, Nowaczyk MJ, Porter FD, Steiner RD, Turecki G.. Cholesterol metabolism and suicidality in Smith-Lemli-Opitz syndrome carriers. Am J Psychiatry2004;161:2123-6.

Kim YK, Myint AM. Clinical application of low serum cholesterol as an indicator for suicide risk in major depression. J Affect Disord 2004;81:161-6.

Berne C, Bjornetorp P. The metabolic syndrome. In: Stress in health and disease. Arnetz BB, Ekman R (Eds).

Wiley India Pvt Ltd, New Delhi; 2006: 317-32.

Hamilton M. A rating scale for depression. J Neurology Neurosurgery Psychiatry 1960; 23: 56-62.

Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-97.

Steegmans PH, Hoes AW, Bak AA, van der Does E, Grobbee DE. Higher prevalence of depressive symptoms in middle-aged men with low serum cholesterol levels. Psychosom Med 2000; 62: 205-11.

Vevera J, Fisar Z, Kvasnicka T, Zdenek H, Stárková L, Ceska R, et al. Cholesterol-lowering therapy evokes time-

limited changes in serotonergic transmission. Psychiatry Res 2005; 133: 197-203.

Published
2008-12-31
How to Cite
1.
Gupta R, Solanki RK, Dubey V, Midha PK, Pathak V. ASSOCIATION OF LIPID PROFILE WITH DEPRESSIVE FEATURES IN YOUNG HYPERTENSIVES. J Pak Psychiatr Soc [Internet]. 2008Dec.31 [cited 2024Nov.22];5(2):101-4. Available from: https://jpps.pk/index.php/journal/article/view/724
Issue
Vol 5 No 2 (2008): Journal of Pakistan Psychiatric Society
Section
Original Article

Copyright © JPPS. Published by Pakistan Psychiatric Society

Licensing: This work is licensed under Creative Commons Attribution-NonCommercial 4.0 International License

Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purposes. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.