GENE DISCOVERY IN SCHIZOPHRENIA AND BIPOLAR DISORDER

Muhammad   Ayub; Douglas   Blackwood

Muhammad Ayub Tees Esk and Wear Valleys NHS Foundation Trust, Flatts Lane Centre, Flatts Lane, Normanby, Middlesborough TS6 OSZ, United Kingdom.
Douglas Blackwood Division of Psychiatry, University ofEdinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF.

Abstract

Over the past few years there have been encouraging advances identifying genetic risk factors in schizophrenia and bipolar disorder and these may be the first steps towards understanding the biology of the disorders leading to novel treatment and preventative strategies. Recently the pace of discovery has increased as new microarray and DNA sequencing technologies now make it possible to survey very large cohorts of patients using many DNA markers to identify some of the many common and rare genetic variants contributing to the disorders. Douglas Blackwood, professor of psychiatric genetics at the University of Edinburgh has been working with Dr Muhammad Ayub, carrying out genetic linkage studies with families from Pakistan with bipolar disorder and depression.

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References

Baum AE, Akula N, Cabanero M, Cardona I, Corona W,Klemens B, et al. A genome-wide association study

implicates diacylglycerol kinase eta (DGKH) and severalother genes in the etiology of bipolar disorder. Mol

Psychiatry 2008; 13: 197-207.

Ferreira MA, O’Donovan MC, Meng YA, Jones IR,Ruderfer DM, Jones L, et al. Collaborative genome-

wideassociation analysis supports a role for ANK3 andCACNA1C in bipolar disorder. Nat Genet 2008;

:1056-8.

International Schizophrenia Consortium. Rare chromo-somal deletions and duplications increase risk of schizo-

phrenia. Nature 2008; 455: 237-41.

O’Donovan MC, Craddock N, Norton N, WilliamsH, Peirce T, Moskvina V, et al. Identification of

lociassociated with schizophrenia by genome-wideassociation and follow-up. Nat Genet 2008; 40.1053-5.

Sklar P, Smoller JW, Fan J, Ferreira MA, PerlisRH, Chambert K, et al. Whole-genome associationstudy of

bipolar disorder. Mol Psychiatry 2008; 13:558-69.

Stefansson H, Rujescu D, Cichon S, Pietiläinen OP,Ingason A, Steinberg S, et al. Large

recurrentmicrodeletions associated with schizophrenia. Nature2008; 455: 232-6.

Wellcome Trust Case Control Consortium. Genome-wideassociation study of 14,000 cases of seven

commondiseases and 3,000 shared controls. Nature 2007; 447:661-78.

Blackwood DH, Fordyce A, Walker MT, St ClairDM, Porteous DJ, Muir WJ. Schizophrenia andaffective

disorders—cosegregation with atranslocation at chromosome 1q42 that directlydisrupts brain-expressed

genes: clinical and P300findings in a family. Am J Hum Genet 2001; 69:428-33.

Murphy KC, Jones LA, Owen MJ. High rates of schizo-phrenia in adults with velo-cardio-facial syndrome. ArchGen

Psychiatry 1999; 56: 940-5.

Ayub M, Irfan M, Maclean A, Naeem F, MacGregor S,Visscher PM, et al. Linkage analysis in a large family from

Pakistan with depression and a high incidence ofconsanguineous marriages. Hum Hered 2008; 66:190-8.

Knight HM, Maclean A, Irfan M, Naeem F, Cass S,Pickard BS, et al. Homozygosity mapping in a family presenting with schizophrenia, epilepsy andhearing impairment. Eur J Hum Genet 2008; 16:750-8.